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About the Index's Methodology

The Loncar Cancer Immunotherapy Index (LCINDX) seeks to track the performance of a transformational therapeutic field within the biotechnology space.  Biotech stocks tend to get grouped together as a whole, yet areas like immunotherapy trade on their own unique circumstances and innovations.  The goal of the Cancer Immunotherapy index is to give investors a better understanding of the immunotherapy sector by highlighting major companies involved and providing a metric to track their progress.  We hope that highlighting immunotherapy in this fashion will lead to more awareness within the investment community, more investment in the field, and more progress for patients who battle cancer disease.


Immunotherapy, or harnessing the body’s own immune system, is changing the way many cancers are treated.  While traditional medicines like chemotherapies often give cancer a broad punch, the benefit of using immunotherapy is derived from the immune system’s dynamic nature and the way it can more precisely be tailored to fight a patient's disease. Interferon alpha (IFN-α), a cytokine, was the first cancer immunotherapy approved in 1986.  Antibody therapies that facilitate the destruction of cancer cells by the immune system have been widely used since 1997, and the first cell-based immunotherapy, a cancer vaccine to treat prostate cancer, was approved in 2010.  Today, many new classes of therapies, including checkpoint inhibitors, next generation vaccines, oncolytic viruses, and chimeric antigen receptor (CAR) technologies, are being developed.  It is the progress of these new therapies that the LCINDX aims to track.


The index was designed to capture contributions from companies both large and small that are leading in this effort.  First, five top large pharmaceutical companies who are working on immunotherapy are chosen.  They are selected both for their strategic focus on immunotherapy, and their leadership role in a specific type of immunotherapy.  Next, the top 25 growth biotechnology companies in immunotherapy by market capitalization are added.  This leaves the portfolio with a target composition of 30 companies.  It is an equal-weighted index and is rebalanced semi-annually.  We believe this mix provides the best way of measuring the field’s growth.


Company inclusion criteria:  All companies included in the LCINDX index must have a high strategic focus on immunotherapy.  In determining whether a company has a high strategic focus on immunotherapy, a company's business must reflect one or more of the following factors:


  • The company has a drug(s) approved by either the FDA or EMA that harnesses the immune system to fight cancer.

  • The company has a drug(s) in the human stage of testing that harnesses the immune system to fight cancer.

  • The company has announced intentions to begin human stage testing of a drug(s) that harnesses the immune system to fight cancer

  • The company has announced an immunotherapy collaboration or partnership with a major pharmaceutical company.


Company exclusion criteria:  The Index Provider excludes from the underlying index companies with any of the following characteristics:


  • The company’s market capitalization is less than $100 million and/or it does not qualify to be in the top 25 biotechnology companies by market capitalization who are leading in this effort.

  • The company's equity liquidity threshold does not surpass 50,000 shares or $500,000 in average daily trading volume.

  • The company is currently under investigation by the SEC or any other government or regulatory entity.


Notwithstanding the foregoing, the Index Provider reserves the right to exclude a company that, while it might meet the foregoing criteria, does not have, either as a company or through its management or scientific research staffs, an established history or credible presence in the field of cancer-focused immunotherpy research and development.


The provider of the LCINDX index is Loncar Investments, LLC., which was founded by independent biotech investor and analyst Brad Loncar.  Mr. Loncar regularly provides his unique insight and analysis on this market segment to the investment community via a variety of publishing platforms.  Through Loncar Investments LLC, Mr. Loncar incorporated his extensive research into biotech companies and technologies to develop this index.  He previously worked in the financial services industry at Franklin Templeton Investments, and was appointed to serve in a Senior Adviser role at the U.S. Department of the Treasury.


Each day the index’s prices and returns are calculated independently by Indxx, LLC.  Quotes can be found under the symbol “LCINDX” on the Bloomberg Professional service,, and other financial data providers.  The inception date for the index was March 18, 2015.


Cancer immunotherapy is a transformational field of research, and we think it is important to have an index that specifically tracks its progress.  We have the highest admiration for the researchers who are working to develop new therapies using this approach, and also for courageous patients who participate in trials that make progress possible.  It is our hope that highlighting immunotherapy in this way will drive more awareness and investment in their direction.


Thank you very much for visiting the site.

Loncar Investments, LLC : P.O Box 15072, Lenexa, KS  66285 : 913-871-5007 : Not investment advice or a solicitation to buy or sell securities

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